Marie Ranson Selected Research

Amiloride (Midamor)

2/2022	Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity.
3/2021	Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.
1/2021	Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
12/2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.
1/2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
11/2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA).
11/2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

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Marie Ranson Research Topics

Disease

35	Neoplasms (Cancer) 10/2022 - 05/2003
24	Neoplasm Metastasis (Metastasis) 02/2022 - 05/2003
9	Breast Neoplasms (Breast Cancer) 08/2020 - 01/2007
8	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2022 - 01/2016
8	Carcinoma (Carcinomatosis) 08/2020 - 07/2004
5	Inflammation (Inflammations) 01/2022 - 06/2011
5	Adenocarcinoma 01/2022 - 04/2017
5	Infections 07/2020 - 01/2004
3	Pre-Eclampsia (Preeclampsia) 01/2022 - 10/2016
3	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2017
3	Prostatic Neoplasms (Prostate Cancer) 12/2021 - 07/2004
2	Thrombosis (Thrombus) 07/2020 - 10/2009
2	Squamous Cell Carcinoma of Head and Neck 01/2020 - 08/2017
2	Streptococcal Infections (Streptococcal Infection) 10/2019 - 01/2013
2	Phlebitis 01/2011 - 10/2009
1	Inborn Genetic Diseases (Disease, Hereditary) 06/2022
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022
1	Neuroblastoma 01/2022
1	Brain Neoplasms (Brain Tumor) 11/2020
1	Pharyngitis (Sore Throat) 11/2020
1	Fibrosarcoma 08/2020
1	Triple Negative Breast Neoplasms 07/2020
1	Hemophilia A (Haemophilia) 07/2020
1	Thrombotic Microangiopathies 07/2020
1	Rheumatoid Arthritis 01/2019
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Oropharyngeal Neoplasms 08/2017
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2017
1	Stomach Neoplasms (Stomach Cancer) 04/2016

Drug/Important Bio-Agent (IBA)

27	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 10/2022 - 05/2003
14	Plasminogen Activators (Plasminogen Activator)IBA 10/2022 - 04/2006
13	PlasminogenIBA 01/2022 - 05/2003
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
8	Plasminogen Activator Inhibitor 2IBA 01/2022 - 07/2004
8	Plasminogen InactivatorsIBA 01/2022 - 07/2004
8	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2016
7	Amiloride (Midamor)FDA LinkGeneric 02/2022 - 11/2011
7	Pharmaceutical PreparationsIBA 12/2020 - 11/2011
6	Urokinase Plasminogen Activator ReceptorsIBA 01/2022 - 04/2011
5	DiureticsIBA 03/2021 - 11/2011
4	Fluorouracil (Carac)FDA LinkGeneric 08/2013 - 10/2009
3	5-(N,N-hexamethylene)amilorideIBA 12/2021 - 01/2018
3	Liposomes (Liposome)IBA 07/2020 - 01/2018
3	Fibrinolysin FDA Link 01/2014 - 08/2006
3	Leucovorin (Folinic Acid)FDA Link 03/2013 - 10/2009
2	SerpinsIBA 01/2022 - 07/2011
2	Amyloid beta-PeptidesIBA 01/2022 - 01/2019
2	trypsin-like serine proteaseIBA 03/2021 - 12/2019
2	Polysaccharides (Glycans)IBA 11/2020 - 01/2020
2	Peptides (Polypeptides)IBA 08/2020 - 01/2008
2	AnticoagulantsIBA 07/2020 - 10/2009
2	Epithelial Cell Adhesion MoleculeIBA 01/2020 - 02/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 08/2017
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2018 - 03/2013
2	PotassiumIBA 01/2018 - 11/2011
2	Plasminogen Activator Inhibitor 1IBA 04/2017 - 12/2007
2	IsatinIBA 01/2016 - 03/2012
2	Serine Proteases (Serine Protease)IBA 11/2011 - 07/2008
2	Lysine (L-Lysine)FDA Link 01/2007 - 05/2003
1	Matrix Metalloproteinases (MMPs)IBA 06/2022
1	dityrosineIBA 01/2022
1	Hypochlorous Acid (Hypochlorite)IBA 01/2022
1	CytokinesIBA 01/2022
1	Protein Isoforms (Isoforms)IBA 12/2021
1	Sodium-Hydrogen ExchangersIBA 03/2021
1	Phosphotransferases (Kinase)IBA 12/2020
1	thulium oxideIBA 11/2020
1	OxidesIBA 11/2020
1	ThuliumIBA 11/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2020
1	IntegrinsIBA 08/2020
1	CollagenIBA 08/2020
1	Hemostatics (Antihemorrhagics)IBA 07/2020
1	Factor V (Coagulation Factor V)IBA 07/2020
1	von Willebrand FactorIBA 07/2020
1	SialyltransferasesIBA 01/2020
1	Keratins (Keratin)IBA 01/2020
1	EnzymesIBA 01/2020
1	Tissue Plasminogen Activator (Alteplase)FDA Link 10/2019
1	Aldehyde Dehydrogenase 1 FamilyIBA 08/2019
1	ThymineIBA 01/2019
1	CytosineIBA 01/2019
1	Drug CarriersIBA 10/2018
1	LigandsIBA 10/2018
1	Edetic Acid (EDTA)FDA Link 02/2018
1	ParaffinIBA 01/2018
1	Peptide Hydrolases (Proteases)FDA Link 01/2018
1	Trastuzumab (Herceptin)FDA Link 01/2018
1	Formaldehyde (Formol)FDA Link 01/2018
1	Immune Checkpoint InhibitorsIBA 08/2017
1	Protein AggregatesIBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 01/2017
1	Sunitinib (Sutent)FDA Link 04/2016
1	Angiogenesis InhibitorsIBA 04/2016

Therapy/Procedure

8	Therapeutics 01/2020 - 05/2009
2	Drug Therapy (Chemotherapy) 01/2018 - 01/2011
2	Catheters 01/2011 - 10/2009
1	Radiotherapy 12/2020
1	Heterologous Transplantation (Xenotransplantation) 12/2020
1	Adjuvant Chemotherapy 01/2018